Changes in Gut Hormones After Roux en Y Gastric bypass, Sleeve Gastrectomy, and Adjustable Gastric Banding

Corresponding author: Miroslav Ilić, Clinic for Thoracic Surgery, Institute for Pulmonary Diseases of Vojvodina, Put doktora Goldmana br. 4, 21204 Sremska Kamenica, Serbia. Telephone: +381/21/480-5100 email: drmiroslavilic@ gmail.com Funding: The authors declare that they have no conflict of interest. This research did not receive any financial support. Conflict of interest: None. Abstract The obesity epidemic has burdened healthcare systems worldwide. Bariatric surgery is currently the most effective method for long-term weight loss in obese adults, but the exact mechanism of weight loss is poorly understood. Bariatric procedures were initially classified by their presumed mechanism of action into restrictive, malabsoptive, or mixed procedures; however, due to recent advancements in the field of neuroendocrinology, hormones are increasing being recognized as important regulators of satiation, hunger, and energy expenditure. Studies examining changes in gut hormones following bariatric surgery have yielded conflicting results and the relationship between these hormones and weight loss is nothing but clear. This review will summarize the effect of Roux en Y gastric bypass, sleeve gastrectomy and adjustable gastric banding on various gut hormones including ghrelin, cholecystokinin, glucagon-like polypeptide-1, peptide YY3, and pancreatic polypeptide. Furthermore, the relationship between these hormones and weight loss will be examined. Miroslav Ilić1, Fuad Pašić2, Lora Kirigin3, Gorana Mirošević3, Miroslav Bekavac Bešlin4